Femara Trumps Clomid as Ovulation Drug






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For years, Clomid has been the leading ovulation drug given to women as a first option ovulation drug. It has been fairly successful, with the majority of women who begin taking it ovulating regularly and becoming pregnant within the first three cycles. However, new research shows that there is another drug this is more powerful than Clomid and does not offer the same side effects.

1. The Study

According to a recent study conducted by Penn State Division of Reproductive Endocrinology, Femara is now believed to be a better choice than Clomid. In fact, it shows that women with Polycystic Ovarian Syndrome (PCOS) have a better chance of ovulating regularly when taking Femara versus taking Clomid.


During this study, 750 women with PCOS were studied by the team. Half of these women were given Femara and the other half was given Clomid. They were given these treatments in five stages and each stage was increased in dosage.

After the study had been completed, the results were recorded as follows:

  • 62% of women were ovulating with Femara
  • 48% of women were ovulating with Clomid
  • 28% of women had successful pregnancies with Femara
  • 19% of women had successful pregnancies with Clomid
  • 3% occurrence of twin pregnancies with Femara
  • 7% occurrence of twin pregnancies with Clomid


It is estimated that 10% of women who are of reproductive age have PCOS. This makes it the leading cause of fertility issues in the United States. PCOS is a disorder where there are issues with a woman’s hormones and they become out of balance. This imbalance causes issues with a woman’s menstrual cycle and can prohibit them from getting pregnant.


There are also a number of other illnesses that can be caused by PCOS. For example, if it goes untreated for an extended period of time illnesses such as diabetes and heart disease can occur. So, even if a woman is not planning to get pregnant soon, it is important for PCOS issues to be addressed as soon as they are discovered.

3. Differences between Clomid and Femara

Femara is often used as a breast cancer treatment and is just starting to become a popular option in the ovulation and fertility worlds. One of the best things about Femara is that many of the side effects that are sometimes reported with Clomid can be avoided.


Some of the worst side effects are: mood swings, thinning of the uterine endometrial lining, reduction of cervical mucus and abdominal discomfort. Both drugs work basically the same way; they both block estrogen receptors in the brain.

This act signals and increase of the production of the hormone that is in the ovaries. Both drugs cost relatively the same amount of money, but with the added benefit of fewer side effects, Femara may become the drug of choice for fertility doctors.

4. What if Clomid is used, but doesn’t work?

Traditionally, if a woman was not able to get pregnant using Clomid, the next step would be to take fertility drugs that were injected. There are many downsides to these drugs.

For starters, many women are nervous around needles and feel uncomfortable injecting themselves with something. Also, there are even more side effects related to these more powerful drugs and the chance of having twins is even greater.


However, now the Femara has been introduced into the picture, women who find that using Clomid has not helped them to get pregnant now have another choice when it comes to a fertility drug. Plus, these injectable fertility drugs are typically rather expensive and Femara will offer a more cost effective option for women who are struggling to get pregnant.

5. Conclusion

There are likely to be continued testing completed between Clomid and Femara. However, early results are promising and it appears that Femara will become the better option, at least for women suffering from PCOS.


These discoveries are important to women because sometimes we struggle to get pregnant. By having more options when it comes to fertility drugs, we now have an even greater chance of getting pregnant and having a successful pregnancy.

If you have been struggling to get pregnant and are looking for some options of fertility drugs to compare, be sure you talk to your doctor about Femara and learn the benefits that it may have for you.

Ms. Ledoux began her career as an ObGyn nurse practitioner prior to becoming a practicing midwife in the Santa Cruz community. Working together with ObGyn physicians in her own practice, she has over 20 years experience in women's health, pregnancy and childbirth.